About the role
Who we are: Kymera is a clinical-stage biotechnology company pioneering the field of targeted protein degradation (TPD) to develop medicines that address critical health problems and have the potential to dramatically improve patients’ lives. Kymera is deploying TPD to address disease targets and pathways inaccessible with conventional therapeutics. Having advanced the first degrader into the clinic for immunological diseases, Kymera is focused on building an industry-leading pipeline of oral small molecule degraders to provide a new generation of convenient, highly effective therapies for patients with these conditions. Founded in 2016, Kymera has been recognized as one of Boston’s top workplaces for the past several years. For more information about our science, pipeline and people, please visit www.kymeratx.com or follow us on X (formerly Twitter) or LinkedIn . How we work: PIONEER : We are courageous, resilient and rigorous in our mission to improve patients’ lives through our revolutionary degrader medicines. COLLABORATE : We value trust + transparency from everyone. Our goals are shared, our decisions data-driven and our camaraderie genuine. BELONG : We recognize our differences, inviting curiosity and inclusivity, so that our people are valued, seen, and heard. How you’ll make an impact: Kymera Therapeutics is seeking an experienced and strategic Associate Director or Director of Statistical Programming to lead programming efforts for a compound-level program spanning multiple clinical studies. This role will be instrumental in ensuring high-quality, timely, and compliant statistical deliverables in support of Kymera's innovative degrader pipeline. The ideal candidate brings 8+ years of statistical programming experience in the pharmaceutical or biotechnology industry, a deep understanding of clinical trial conduct, data flow, and regulatory expectations, and the ability to balance strategic leadership with hands-on programming. This individual will proactively identify risks, solve complex problems, and collaborate effectively with cross-functional stakeholders and external partners. Lead statistical programming for a compound-level program, including programming strategy, timelines, and resource planning, to ensure timely, accurate, and regulatory-compliant deliverables. Partner with Biostatistics, Clinical Development, Data Management, Clinical Operations, and other cross-functional teams to align on timelines, priorities, and quality expectations. Partner with the PK/PD function to manage the blinded data process during the double-blind period, ensuring role-based data access in line with the blinded data management plan. Help coordinate the process for ongoing data review across programming, data management, and study team stakeholders, including data transfers and the delivery of required outputs. Oversee CROs and external vendors delivering SDTM, ADaM, and TLF outputs, with a focus on technical quality, consistency, and clear documentation. Manage in-house programming projects, including setting up and maintaining the programming workflow (e.g., task assignment, validation, version control, and delivery) and overseeing in-house programmers. Write SDTM and ADaM specifications, and develop, validate, and maintain datasets and TLFs to support data review, CSRs, publications, and ad hoc data requests. Support programming for regulatory submissions (e.g., Define-XML, ADRG/SDRG, eCTD) and provide documentation and expertise for audits and inspections. Contribute to department standards, processes, and tools, including automation and AI-enabled tools; mentor programmers as needed. Additional duties and responsibilities as required. Skills and experience you’ll bring: MS or equivalent degree in Statistics, Biostatistics, Computer Science, or a related field (BS with substantial relevant experience will be considered). 8+ years of statistical programming experience in the pharmaceutical or biotechnology industry, including experience supporting Phase I, II, and III clinical trials. Demonstrated leadership of programming activities for a compound-level program, with proven experience influencing across functions. Proven experience overseeing CROs and external vendors, with accountability for quality, timelines, and deliverables. Deep, hands-on expertise with CDISC standards (SDTM, ADaM, Define-XML) and strong knowledge of regulatory submission requirements (e.g., NDA/MAA, eCTD); prior experience leading or contributing to at least one successful submission. Hands-on experience writing SDTM and ADaM specifications and setting up and managing in-house programming workflows and projects, including task allocation, validation, and quality control. Advanced SAS programming proficiency, with proven ability to independently produce high-quality analysis datasets, tables, listings, and figures, including for ad hoc data requests. Strong expertise in programming and analyzing efficacy endpoints, with the ability to efficiently translate clinical objectives into analysis-ready datasets and outputs. Experience supporting blinded data processes in double-blind studies is strongly preferred. Demonstrated ability to collaborate effectively in cross-functional settings, adapt quickly to a fast-paced or startup environment, and manage competing timelines and priorities while maintaining quality. Quick learner who writes efficient, well-organized, well-documented code and adapts readily to changing requests. Proactive, solutions-oriented mindset with excellent communication and leadership skills. Experience with R or Python is a plus. Equal Employment Opportunity Kymera Therapeutics is proud to be an equal opportunity employer, seeking to create a welcoming and diverse environment. All applicants will receive consideration for employment without regard to race, color, religion, creed, gender, national origin, age, disability, veteran status, pregnancy, sex, marital status, gender expression or identity, genetic information, sexual orientation, citizenship, or any other legally protected class. Compensation Kymera offers a competitive compensation package that recognizes both results and capabilities through market-based, performance-driven pay. The anticipated base salary range for this role is $160,000 – $275,000, with eligibility for annual bonus, equity participation, and comprehensive benefits. Actual salary is based on a holistic evaluation of the specific role/level as well as each candidate’s depth of experience and the capabilities they bring to the position.