About the role
Overview The Bioanalytical Sciences group at Alnylam is seeking a highly motivated Associate Scientist II specializing in ligand-binding assays and immunoassays for the quantification of oligonucleotides, proteins, peptides, and antibodies. This individual will focus on high-quality sample analysis using established methods, generating reliable data to inform drug exposure, target engagement, pharmacodynamic (PD) responses, and biomarker endpoints across preclinical species and biological matrices, supporting the advancement of RNAi therapeutics. The ideal candidate takes pride in executing assays with precision, can manage large sample sets efficiently, and maintains meticulous records. They will have a background in biochemical, pharmaceutical, or biological sciences, strong hands-on bench skills, and exceptional attention to detail. This individual will thrive in a fast-paced, goal-oriented environment. This is an exciting opportunity to join a vibrant team and interact with highly motivated scientists across a broad array of disciplinary expertise areas. This position is onsite and will be primarily located in Cambridge, MA . Key Responsibilities Perform routine, high-throughput, non-GLP sample analysis using established ligand-binding assays (ELISA, hybridization ELISA, MSD, Quanterix, and ELLA) and immunoassays (Western blot and Jess) to support pharmacokinetic (PK), target engagement, and pharmacodynamic (PD) assessments across a variety of biological matrices. Execute end-to-end sample analysis workflows, including sample organization and reconciliation, sample preparation and tissue homogenization, plate layout, assay execution, data processing, and quality control (QC) review, in accordance with established methods and study plans. Apply assay acceptance criteria to standard curves and quality controls; identify and flag failed runs, outliers, and trends; and perform repeat analyses as needed. Maintain accurate, contemporaneous electronic laboratory notebook (ELN) records and organize raw data, analysis files, and results to ensure they are traceable, review-ready, and readily accessible to the team. Maintain appropriate procedures and controls to ensure consistent assay performance and reproducible data. Communicate sample status, timelines, and data to the supervisor and study teams; prioritize multiple studies to meet timelines program deliverables. Contribute to workflow efficiency through batching, automation, and standardized templates, and support assay transfers or bridging as needed. Learn in-depth knowledge about the technologies and platforms used to generate results to help troubleshoot, address queries, and present data to diverse groups within. Qualifications Bachelors or degree in a scientific discipline with 1-3 years of relevant laboratory experience or Master degree with 1 year of relevant laboratory experience. Hands-on molecular laboratory experience with techniques such as ELISA, Western blotting, and qPCR. Strong pipetting and bench technique with demonstrated ability to generate reproducible data across large sample sets. Highly organized and detail-oriented, with meticulous record keeping practices. Ability to manage multiple projects effectively in a fast-paced team environment. Proficiency in Excel, Word, and PowerPoint. Experience with additional analytical software, such as GraphPad Prism, SoftMax, or Discovery Workbench, is preferred. Clear verbal and written communication skills, with the ability to collaborate effectively across teams. About Alnylam We are the leader in RNAi therapeutics – a revolutionary approach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possible and are just at the beginning of what’s possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, where an authentic, inclusive culture and breakthrough thinking fuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer. Before applying, please review Alnylam's Candidate Privacy Notice regarding how Alnylam handles Personal Data you provide with your application for employment. The pay range below reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam’s robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: https://www.alnylam.com/careers U.S. Pay Range $67,600 - $101,400 USD